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sigmoidal dose-response (variable slope) non-linear regression model  (GraphPad Software Inc)


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    GraphPad Software Inc sigmoidal dose-response (variable slope) non-linear regression model
    Sigmoidal Dose Response (Variable Slope) Non Linear Regression Model, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/non-linear+regression%2C+sigmoidal+dose-response+model/sigmoidal+dose+response+curve/pmc08946243-137-38-45
    Average 90 stars, based on 1 article reviews
    sigmoidal dose-response (variable slope) non-linear regression model - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    In Vitro:

    Article Title: Initial Testing (Stage 1) of Temozolomide by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs. the log-transformed concentration (X) for the in vitro PPTP study data: Y = Bottom + Top - Bottom 1 + 10 ( LogrIC 50 - X ) × HillSlope The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the T/C% values at low and high concentrations, respectively.

    Article Title: Initial Testing (Stage 1) of M6620 (formerly VX-970), a Novel ATR Inhibitor, alone and combined with Cisplatin and Melphalan, by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs . the log-transformed concentration (X) for the in vitro PPTP study data: Y = Bottom + (Top-Bottom)/(1 + 10^((LogrlC 50 -X) ∗ HillSlope)) The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the Treatment/Control (T/C%) values at low and high concentrations, respectively.

    Article Title: Initial Testing (Stage 1) of the Phosphatidylinositol 3’ Kinase Inhibitor, SAR245408 (XL147) by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs . the log-transformed concentration (X) for the in vitro PPTP study data: Y =\u00a0Bottom +\u00a0(Top\u00a0\u2212\u00a0Bottom)/(1 +\u00a010^((LogrIC 50 \u2212X) * HillSlope)) The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the T/C% values at low and high concentrations, respectively.

    Fluorescence:

    Article Title: Initial Testing (Stage 1) of Temozolomide by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs. the log-transformed concentration (X) for the in vitro PPTP study data: Y = Bottom + Top - Bottom 1 + 10 ( LogrIC 50 - X ) × HillSlope The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the T/C% values at low and high concentrations, respectively.

    Article Title: Initial Testing (Stage 1) of M6620 (formerly VX-970), a Novel ATR Inhibitor, alone and combined with Cisplatin and Melphalan, by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs . the log-transformed concentration (X) for the in vitro PPTP study data: Y = Bottom + (Top-Bottom)/(1 + 10^((LogrlC 50 -X) ∗ HillSlope)) The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the Treatment/Control (T/C%) values at low and high concentrations, respectively.

    Article Title: Initial Testing (Stage 1) of the Phosphatidylinositol 3’ Kinase Inhibitor, SAR245408 (XL147) by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs . the log-transformed concentration (X) for the in vitro PPTP study data: Y =\u00a0Bottom +\u00a0(Top\u00a0\u2212\u00a0Bottom)/(1 +\u00a010^((LogrIC 50 \u2212X) * HillSlope)) The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the T/C% values at low and high concentrations, respectively.

    Concentration Assay:

    Article Title: Initial Testing (Stage 1) of Temozolomide by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs. the log-transformed concentration (X) for the in vitro PPTP study data: Y = Bottom + Top - Bottom 1 + 10 ( LogrIC 50 - X ) × HillSlope The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the T/C% values at low and high concentrations, respectively.

    Article Title: Initial Testing (Stage 1) of M6620 (formerly VX-970), a Novel ATR Inhibitor, alone and combined with Cisplatin and Melphalan, by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs . the log-transformed concentration (X) for the in vitro PPTP study data: Y = Bottom + (Top-Bottom)/(1 + 10^((LogrlC 50 -X) ∗ HillSlope)) The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the Treatment/Control (T/C%) values at low and high concentrations, respectively.

    Article Title: Initial Testing (Stage 1) of the Phosphatidylinositol 3’ Kinase Inhibitor, SAR245408 (XL147) by the Pediatric Preclinical Testing Program
    Article Snippet: For analysis of in vitro testing results, a non-linear regression, sigmoidal dose-response model was fitted using GraphPad Prism 5.03 to the relative mean fluorescence values vs . the log-transformed concentration (X) for the in vitro PPTP study data: Y =\u00a0Bottom +\u00a0(Top\u00a0\u2212\u00a0Bottom)/(1 +\u00a010^((LogrIC 50 \u2212X) * HillSlope)) The terms are defined as follows: rIC 50 (relative IC 50 ) is the concentration of agent that gives a response half way between Bottom and Top; HillSlope describes the steepness of the dose-response curve; and Top and Bottom are the plateaus in the T/C% values at low and high concentrations, respectively.



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